Eye Reports https://eyereports.org/index.php/eyereports <p><strong>Eye Reports</strong> is a new peer-reviewed international medical journal devoted entirely to the study, diagnosis, and treatment of all eye-related diseases. The journal covers the pathophysiology, diagnosis, classification, epidemiology and treatment of ophthalmic diseases for physicians and medical scientists. The primary intent of the journal will be to publish clinically relevant information that will directly improve the care of patients with such diseases. Basic science studies of interest to those treating disorders will also be considered for publication when relevant.</p><strong></strong> en-US <div>Eye Reports has chosen to apply the <a href="http://creativecommons.org/licenses/by-nc/3.0/" target="_blank">Creative Commons Attribution NonCommercial 3.0 License</a> (CC BY-NC 3.0) to all manuscripts to be published. <br /><br />An Open Access Publication is one that meets the following two conditions:<br /><br /> 1. The author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use.<br /> 2. 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Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. 3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.</div> editor@eyereports.org (Neal Adams, MD) manager@eyereports.org (Mr. H. Stelling Leader, Administrative Manager) Mon, 16 Nov 2020 18:22:44 -0800 OJS 3.3.0.11 http://blogs.law.harvard.edu/tech/rss 60 Discovery of a novel genetic variation in papillorenal syndrome https://eyereports.org/index.php/eyereports/article/view/101 <p>Renal coloboma syndrome or papillorenal syndrome is an autosomal dominant genetic disorder characterized by congenital renal and ocular disorders associated with variations in the <em>PAX2 </em>gene. In this case report, a 46-year-old gentleman presented for ocular examination in the setting of systemic hypertension. Past medical history included a kidney transplant due to renal failure. Fundus examination revealed bilateral optic nerve abnormalities with a large central excavation, with numerous vessels radiating from the periphery of the optic disc, consistent with the Morning Glory anomaly. Optical coherence tomography (OCT) disclosed substantial thinning of retinal nerve fiber layer. Genetic studies revealed the heterozygous variant c.398delC in the 3’ exon of <em>PAX2 </em>gene not previously described in the peer-reviewed medical literature (searched using MEDLINE and cross-referenced literature).</p> Irune Ortega Renedo, Ana Ibáñez Muñoz, Cristina Ibáñez Muñoz, María Rozanova Klecheva, Leticia Rodríguez Vicente, Jensy Sosa Durán, José Luis del Río Mayor Copyright (c) https://eyereports.org/index.php/eyereports/article/view/101 Mon, 16 Nov 2020 00:00:00 -0800 Correlation of the cholesterol-to-high-density-lipoprotein Castelli risk index-1 with the choroidal and retinal nerve fiber layer thickness in patients with diabetes mellitus without retinopathy https://eyereports.org/index.php/eyereports/article/view/104 <div><p><strong>Purpose: </strong>To determine the choroidal thickness and retinal nerve layer (RNFL) thickness changes in patients with diabetes mellitus (DM) without retinopathy in relation to their glycated hemoglobin (HbA1c) and Castelli risk index-1 (CRI-1) levels.</p><p><strong>Method: </strong>This study examined the right eyes of 340 subjects. CRI-1 was calculated as the total cholesterol divided by high-density lipoprotein cholesterol. Five groups of 68 eyes were defined as follows: Group 1, control group consisting of healthy subjects; Group 2, DM patients with HbA1c from 7% to 9%; Group 3, DM patients with HbA1c from 7% to 9% and CRI-1 greater than 4; Group 4, DM patients with HbA1c greater than 9.1%; and, Group 5, DM patients with HbA1c greater than 9.1% and with CRI-1 greater than 4. Optical coherence tomography (OCT) measurements were taken using enhanced depth imaging. Choroidal thickness (CT) and RNFL thickness were compared within groups.</p><p><strong>Results: </strong>CT was found to be lower in all DM groups compared with healthy subjects. In all nasal areas, CT was significantly thinner in group 5 than group 4. RNFL loss was only seen in the inferior temporal quadrant of all DM patients compared with the control group. There was no statistically significant difference between subgroups in RNFL measurements.</p><p><strong>Conclusion: </strong>CRI-1, which is a marker of combined dyslipidemia abnormalities, is in use to predict atherosclerotic changes in DM patients. This study determined the CRI-1 also correlates with the CT of diabetic eyes but not the RNFL, and it can be used as an additional criterion in ophthalmological follow-ups of diabetic patients.</p></div><strong></strong> Zeynep Eylul Ercan Copyright (c) https://eyereports.org/index.php/eyereports/article/view/104 Mon, 16 Nov 2020 00:00:00 -0800 Primary ocular sporotrichosis with granulomatous conjunctivitis https://eyereports.org/index.php/eyereports/article/view/106 <p>Sporotrichosis is an infection which is caused by the dimorphic fungus <em>Sporothrix schenckii</em>. Primary ocular sporotrichosis is uncommon in non-endemic areas and may be easily misdiagnosed, leading to a delay in initiation of treatment. In this case report, a 15-year-old girl, who is a post renal transplant patient presented with left eye swelling and localized redness at the medial canthal region. She was initially treated with topical antibiotics but there was no improvement. The addition of topical steroids led to the development of multiple nodules with central ulceration. Examination of the left eye showed granulomatous conjunctivitis. The features were suggestive of sporotrichosis and she was empirically started on oral itraconazole. A biopsy of the lesion showed caseating granulomatous inflammation and fungal PCR tested positive for <em>Sporothrix schenckii</em>. Her symptoms and clinical findings completely resolved after 3 weeks on itraconazole; however, her liver function deteriorated, and patient opted to discontinue the medication.</p> Hsin Yi Lee, Norlina Ramli, Gayathri Govindasamy, Joon Hi Tham, Siew Yuen Goh Copyright (c) https://eyereports.org/index.php/eyereports/article/view/106 Mon, 16 Nov 2020 00:00:00 -0800 Bird pecking ocular injury caused by a native Malayan bird https://eyereports.org/index.php/eyereports/article/view/102 <div><p>Eye injuries resulting from bird pecking are rare but may cause permanent blindness. We report a case of penetrating ocular injury following a peck by a white-breasted waterhen. A 13-year-old girl presented with painful visual loss in her left eye after being pecked by her pet bird. She sustained a central corneal laceration and traumatic cataract in her left eye. Primary closure of corneal laceration was performed without complication. Broad spectrum topical and intravenous antibiotics were administered. After two weeks, she developed a mature white cataract. Subsequently, she underwent lens aspiration with intraocular lens implantation. Her vision improved drastically from 20/2400 to 20/60. Precautions should be taken while handling birds, especially when children are handling birds, in order to prevent any ocular injury. Parents play a vital role in preventing their child from getting injured by birds.</p></div> Logeswari Krishna, Nor Aisyah Zakaria, Sujaya Singh, May May Choo, Pooi Wah Lott Copyright (c) https://eyereports.org/index.php/eyereports/article/view/102 Mon, 16 Nov 2020 00:00:00 -0800 Hemi-forehead lifting for upper eyelid and brow ptosis in neurofibromatosis type 1 https://eyereports.org/index.php/eyereports/article/view/96 <div><p>A 63-year-old female patient presented with ptosis in the right eyelid, wrinkles in the right half of the forehead, and narrowing of visual field. She had been diagnosed with giant plexiform neurofibroma. In addition, she had painless, non-tender soft masses on her left shoulder and neck. The patient's ptosis and forehead wrinkles improved in the supine position but were more prevalent in the vertical position. She had undergone blepharoplasty in the previous year. She did not have any disease history other than mild ptosis in the right and a mass in the neck that was present since puberty but had grown within the last decade. Pretrichial hemi-forehead and brow lift for eyebrow ptosis and forehead wrinkles was planned and performed without any complications in the early postoperative period and no recurrence in the 18-month follow-up period.</p></div> Erol Havuz Copyright (c) https://eyereports.org/index.php/eyereports/article/view/96 Mon, 16 Nov 2020 00:00:00 -0800