Cracking the code to the 2019 novel coronavirus (COVID-19): Lessons from the eye

Neal Adams

Abstract


With the recent March 11, 2020 declaration of a pandemic by the World Health Organization (WHO), further attention has turned to understanding and managing the outbreak of infectious disease termed coronavirus disease 2019 (COVID-19) caused by the novel coronavirus identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).  The SARS-CoV-2 gains entry into human cells through its ability to bind to a human ACE2 protein.  Through our understanding of diabetic retinopathy, there are genetic-based variations in ACE2 levels that confer varying risk profiles for diabetic retinopathy.  Similarly, emerging research suggests ACE2 levels confer varying risk profiles for COVID-19.  Using data comparisons between geographic prevalence rates of diabetic retinopathy and existing COVID-19 mortality rates may enable improved predictions of the rates of spread of COVID-19 in various geographic regions.  The goal of this report is to encourage cross-disciplinary horizontal vision in the field of medicine and science in order to further progress in managing and treating human disease.


Keywords


2019 coronavirus; COVID-19; coronavirus 2; SARS coronavirus; SARS; SARS-CoV; SARS-CoV-2; ACE; ACE2; angiotensin converting enzyme; diabetes; diabetic retinopathy; geography; ethnicity; geographic area; geographic region; genetic; heredity; china; us

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DOI: http://dx.doi.org/10.16964/er.v6i1.97

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